Tissue Transglutaminase IgA (tTG IgA)
The Tissue Transglutaminase IgA (tTG IgA) test is a blood test used to help diagnose celiac disease. It measures the presence of specific antibodies in the blood that indicate an immune response to gluten. Elevated tTG IgA levels suggest celiac disease, an autoimmune disorder where gluten triggers an immune response that damages the small intestine.
Elaboration:
Celiac Disease Diagnosis:
The Tissue Transglutaminase IgA (tTG IgA) test is a blood test used to help diagnose celiac disease. It measures the presence of specific antibodies in the blood that indicate an immune response to gluten. Elevated tTG IgA levels suggest celiac disease, an autoimmune disorder where gluten triggers an immune response that damages the small intestine.
Gluten Sensitivity:
The test can also help assess gluten sensitivity, even in cases where the individual might not have full-blown celiac disease.
Immune Response:
In celiac disease, the immune system mistakenly identifies gluten as a foreign invader and produces antibodies, including tTG IgA antibodies, against it.
Test Procedure:
The test involves a simple blood draw, with a small amount of blood collected for analysis.
Interpretation:
Elevated tTG IgA levels are a strong indicator of celiac disease and often warrant further testing, such as an endoscopy.
Other Uses:
The tTG IgA test can also be used to monitor the effectiveness of a gluten-free diet in individuals with celiac disease.
Accurate Diagnosis:
This test, along with other tests like anti-gliadin antibodies, helps doctors accurately diagnose celiac disease and distinguish it from other conditions.